Main Molecular Factors and Pathways in the Anti-cancer Act of Crocin

Document Type : Letter to editor



One of the herbal materials with several anti-inflammatory and antioxidant characteristics is crocin, an effective component derived from saffron, which can be applied to cure a range of diseases. It has been demonstrated that crocin has an important impact on controlling pathological situations such as inflammation, oxidative stress, neurodegenerative diseases, metabolic disorders, and cancer. Notch, PI3K/AKT/mTOR, and cyclic-AMP response element-connecting factor pathways may all be involved in crocin's neuroprotective properties. With its inhibitory effect on toll-like receptors, crocin also preserves the cardiovascular system. Treatment of metabolic problems may be performed by crocin's regulatory influence on the PI3K pathway, mitogen-activated protein kinases, and peroxisome proliferator-stimulated receptor pathways. This letter has investigated effective molecular factors in the anticancer act of crocin.