A New Approach to the Investigation of Therapeutic Efficiency of Novel Carum copticum Nanoparticles against Leishmania major Promastigotes

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Abstract

Current therapies for Leishmaniasis are associated with several side effects as well as drug resistance. Sensitivity and resistance of Leishmania major to Glutamine are referred to as those isolates which are responsive or non-responsive to one or two full courses of treatment by Glucantime systematically and/or intra-lesionally, respectively. In this study, We assessed a new approach to the investigation of the therapeutic efficiency of novel Carum copticum Nanoparticles against Leishmania major Promastigotes. First, the Carum copticum Nanoparticles were synthesized and liposomal Carum copticum was applied as a new therapeutic approach substituted for current therapy. In this experimental study, liposomal Carum copticum was prepared using the thin film hydration method and characterized based on encapsulation efficiency, size, and zeta potential. Carum copticum was successfully loaded into the liposome. The surface charge of the nanoparticle was neutral and the size of the nanoparticle was 176.5 nm. Liposomal Carum copticum beared spherical shape without any agglomeration. Results revealed that liposomal Carum copticum carried a significant effect, compared to the control sample, on parasite growth in both logarithmic and stationary phases. The result of this study signifies that the Carum copticum Nanoparticles induces a better and more tangible effect on the survival of Leishmania major promastigotes.

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